SR 1078

Research use only, not for human use.

SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ.

SR-1078 is a selective agonist of RORα and RORγ that stimulates ROR transcriptional activity in HEK293 cell reporter assays at concentrations as low as 2 μM without effect at the related liver X receptors and farnesoid X receptors. SR1078 modulates the conformation of RORγ in a biochemical assay and activates RORα and RORγ driven transcription. SR1078 stimulates expression of endogenous ROR target genes in HepG2 cells that express both RORα and RORγ. SR1078 can be utilized as a chemical tool to probe the function of these receptors both in vitro and in vivo.

SR-1078; SR 1078; SR1078

GPCR/G Protein

Antibacterial

RORα;RORγ

Cancer

——

1246525-60-9

431.25

C17H10F9NO2

98%

DMSO : 33.33 mg/mL 77.29 mM;

OC(c1ccc(NC(=O)c2ccc(cc2)C(F)(F)F)cc1)(C(F)(F)F)C(F)(F)F

N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-4-(trifluoromethyl)benzamide

(-20℃)

With Ice Pack

≥ 2 years